The film revolves around a cadaver who seems to bring misfortune on those who come in contact with it.
Although there is very little corporeal manifestation of the ghosts, people seem to die when they enrage the spirit which is linked with a special cadaver—by disrespecting it or otherwise. The story takes place mostly inside a hospital, where a young medical student, Alison Blanchard, comes to learn anatomy. By observing the cadaver she was assigned, she discovers that the body had self-inflicted wounds and also had a child. She soon discovers that there is something wrong with the cadaver, which they have nicknamed “Norma.” Mysterious deaths occur in the hospital, which include the fiancée of one of Allison’s team members and several hospital employees.

It is revealed that the cadaver is a person named Alita Covas, who once led an archaeological expedition on an Aztec sacrificial site. There she uncovered 50,000 bodies which were offered to Tlazolteotl, the Aztec god of fertility and prostitution. Afterwards, she herself became a prostitute, and started showing symptoms of mental imbalance. Later in her life, she committed murders and was subsequently put in a mental asylum where she died—presumably by her own hand.

Once Alison learns of the true nature of the cadaver, she decides the corpse must return to Brazil to satisfy the Aztec god. After a series of gruesome events, Alison and her classmate/love interest take Alita’s now dismembered corpse and cremate her in the hospital. In the end, Alison heads to Brazil to spread the ashes in an attempt to put the spirit at rest; however, it is suggested in the final scene that the spirit remains in the .